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Comment
. 2016 Aug 30;113(35):9670-2.
doi: 10.1073/pnas.1611899113. Epub 2016 Aug 10.

The heart in sickle cell disease, a model for heart failure with preserved ejection fraction

John C Wood  1
Affiliations
Comment

The heart in sickle cell disease, a model for heart failure with preserved ejection fraction

John C Wood. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
(Left) Schematic linking sickle hemoglobin to the multiple mechanisms by which it produces vascular damage. Broadly, these are divided into those caused by direct mechanical interactions of the red cell and endothelium and those caused by premature red cell destruction. (Right) Major organ systems affected in sickle cell disease; many organs experience both infarctions and interstitial fibrosis.
See this image and copyright information in PMC

Comment on

  • Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology.
    Bakeer N, James J, Roy S, Wansapura J, Shanmukhappa SK, Lorenz JN, Osinska H, Backer K, Huby AC, Shrestha A, Niss O, Fleck R, Quinn CT, Taylor MD, Purevjav E, Aronow BJ, Towbin JA, Malik P. Bakeer N, et al. Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5182-91. doi: 10.1073/pnas.1600311113. Epub 2016 Aug 8. Proc Natl Acad Sci U S A. 2016. PMID: 27503873 Free PMC article.

References

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