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Case Reports
. 2016 Jul-Aug;26(4):284-7.
doi: 10.4103/0971-4065.169566.

Lupus podocytopathy: An important differential diagnosis of nephrotic syndrome in systemic lupus erythematosus

A R Chaudhury  1 , T Rajarajan  2 , R Yousuf  1 , E Fernando  2 , A A Kurien  3
Affiliations
Case Reports

Lupus podocytopathy: An important differential diagnosis of nephrotic syndrome in systemic lupus erythematosus

A R Chaudhury et al. Indian J Nephrol. 2016 Jul-Aug.

Abstract

Some patients with systemic lupus erythematosus (SLE) present with sudden onset of nephrotic syndrome and biopsy findings may be of minimal change disease or focal segmental glomerulosclerosis with diffuse foot process effacement on electron microscopy but without significant immune deposits. This entity is termed lupus podocytopathy. Clinicians and renal pathologists need to be aware of this condition. Though steroid sensitive, it needs follow-up to recognize flare and class change, thereby optimizing therapy.

Keywords: Electron microscopy; lupus podocytopathy; systemic lupus erythematosus.

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Figures

Figure 1
Figure 1
Electron micrograph of a portion of a glomerulus shows diffuse effacement of foot processes of podocytes. Note that there are no electron dense deposits in the subepithelial, subendothelial or mesangial areas
Figure 2
Figure 2
Segmental sclerosis with adhesions to the Bowman's capsule (Trichrome, ×400)
See this image and copyright information in PMC

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References

    1. Appel GB, Silva FG, Pirani CL, Meltzer JI, Estes D. Renal involvement in systemic lupud erythematosus (SLE): a study of 56 patients emphasizing histologic classification. Medicine (Baltimore) 1978;57:371–410. - PubMed
    1. Jennette JC, Olson JL, Silva FG, D'Agati VD. Heptinstalls Pathology of the Kidney. 7th ed. Philadelphia, USA: Wolters Kluwer; 2015. pp. 608–9.
    1. Dube GK, Markowitz GS, Radhakrishnan J, Appel GB, D'Agati VD. Minimal change disease in systemic lupus erythematosus. Clin Nephrol. 2002;57:120–6. - PubMed
    1. Kraft SW, Schwartz MM, Korbet SM, Lewis EJ. Glomerular podocytopathy in patients with systemic lupus erythematosus. J Am Soc Nephrol. 2005;16:175–9. - PubMed
    1. Matsumura N, Dohi K, Shiiki H, Morita H, Yamada H, Fujimoto J, et al. Three cases presenting with systemic lupus erythematosus and minimal change nephrotic syndrome. Nihon Jinzo Gakkai Shi. 1989;31:991–9. - PubMed

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