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Case Reports
. 2016 Jul-Aug;26(4):298-301.
doi: 10.4103/0971-4065.179368.

Lymphoblastic lymphoma presenting as bilateral renal enlargement diagnosed by percutaneous kidney biopsy: Report of three cases

V Rajakumar  1 , V Balaraman  2 , R Balasubramaniam  3 , S Shankar  4 , T S Ganesan  5 , A A Kurien  6
Affiliations
Case Reports

Lymphoblastic lymphoma presenting as bilateral renal enlargement diagnosed by percutaneous kidney biopsy: Report of three cases

V Rajakumar et al. Indian J Nephrol. 2016 Jul-Aug.

Abstract

Renal involvement by lymphoma can be a diagnostic challenge. Acute kidney injury (AKI) is an unusual manifestation of lymphomatous infiltration in the kidneys. We report three cases of lymphoblastic lymphoma, a very rare form of lymphoma, presenting with AKI and bilateral enlargement of kidneys, diagnosed by percutaneous kidney biopsy. Lymphomatous infiltration should be suspected with such clinical presentation. Kidney biopsy is a valuable diagnostic tool, to establish the correct diagnosis and subtype of lymphoma for timely initiation of therapy for these aggressive hematological malignancies.

Keywords: Acute kidney injury; kidney biopsy; lymphoblastic lymphoma; renal lymphoma infiltration.

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Figures

Figure 1
Figure 1
Magnetic resonance imaging showing bilaterally enlarged kidneys (Case 1)
Figure 2
Figure 2
Renal biopsy of Case 2: Lymphoid cells diffusely infiltrate the renal parenchyma. H and E, ×100 (Case 2)
Figure 3
Figure 3
Lymphoma cells strongly express CD20, PAX5, CD10 and terminal deoxynucleotidyl transferase. They are negative for CD3 and CD34, confirming the diagnosis of precursor B-lymphoblastic lymphoma/leukemia (Case 3)
See this image and copyright information in PMC

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