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. 2016 Mar-Jun;16(1-2):53-60.
doi: 10.1080/09723757.2016.11886278.

piRNAs and Their Functions in the Brain

Lingjun Zuo  1 , Zhiren Wang  2 , Yunlong Tan  2 , Xiangning Chen  3 , Xingguang Luo  4
Affiliations

piRNAs and Their Functions in the Brain

Lingjun Zuo et al. Int J Hum Genet. 2016 Mar-Jun.

Abstract

Piwi-interacting RNAs (piRNAs) are the non-coding RNAs with 24-32 nucleotides (nt). They exhibit stark differences in length, expression pattern, abundance, and genomic organization when compared to micro-RNAs (miRNAs). There are hundreds of thousands unique piRNA sequences in each species. Numerous piRNAs have been identified and deposited in public databases. Since the piRNAs were originally discovered and well-studied in the germline, a few other studies have reported the presence of piRNAs in somatic cells including neurons. This paper reviewed the common features, biogenesis, functions, and distributions of piRNAs and summarized their specific functions in the brain. This review may provide new insights and research direction for brain disorders.

Keywords: Biogenesis; Brain; Distribution; Function; piRNA.

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References

    1. Adams NC, Tomoda T, Cooper M, Dietz G, Hatten ME. Mice that lack astrotactin have slowed neuronal migration. Development. 2002;129:965–972. - PubMed
    1. Akkouche A, Grentzinger T, Fablet M, Armenise C, Burlet N, et al. Maternally deposited germline piRNAs silence the tirant retrotransposon in somatic cells. EMBO Rep. 2013;14:458–464. - PMC - PubMed
    1. Angrand PO, Segura I, Volkel P, Ghidelli S, Terry R, et al. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Mol Cell Proteomics. 2006;5:2211–2227. - PubMed
    1. Aravin A, Gaidatzis D, Pfeffer S, Lagos-Quintana M, Landgraf P, et al. A novel class of small RNAs bind to MILI protein in mouse testes. Nature. 2006;442:203–207. - PubMed
    1. Aravin AA, Hannon GJ, Brennecke J. The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science. 2007a;318:761–764. - PubMed

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