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Review
. 2016 Jun;9(2):55-9.
doi: 10.1177/1753495X15626623. Epub 2016 Feb 24.

Two case reports of generalized pustular psoriasis of pregnancy: Different outcomes

Aoibheann Flynn  1 , Naomi Burke  2 , Bridgette Byrne  3 , Noreen Gleeson  2 , Bairbre Wynne  1 , Louise Barnes  1
Affiliations
Review

Two case reports of generalized pustular psoriasis of pregnancy: Different outcomes

Aoibheann Flynn et al. Obstet Med. 2016 Jun.

Abstract

Generalized pustular psoriasis of pregnancy is a rare dermatosis with potential serious consequences for both the mother and fetus. Treatment is difficult and historically steroids were the mainstay of treatment. Cyclosporin has been used for a few cases resistant to steroids. We report our own experience of two cases of generalized pustular psoriasis of pregnancy. Cases of generalized pustular psoriasis of pregnancy need review by a dermatologist with experience of skin disorders in pregnancy. Both the fetus and mother need to be monitored closely when systemic illness occurs, as there is a risk of stillbirth. Maternal sepsis is a known complication of generalized pustular psoriasis of pregnancy. Cyclosporin, when used appropriately is effective and relatively safe.

Keywords: Generalized pustular psoriasis; cyclosporin; pregnancy; sepsis.

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Figures

Figure 1.
Figure 1.
Erythematous plaques studded with sterile pustules peripherally.
Figure 2.
Figure 2.
Histopathology of a skin biopsy shows subcorneal pustules with neutrophilic infiltration.
Figure 3.
Figure 3.
Sheaths of pustules and erythema across abdomen and upper thighs.
Figure 4.
Figure 4.
Erythematous plaques with sheaths of pustules.
See this image and copyright information in PMC

References

    1. Vaughan-Jones SA, et al. Skin disease in pregnancy. Br Med J 2014; 348: 3489–3489. - PubMed
    1. Shaw CJ, Wu P and Sriemevan A. First trimester impetigo herpetiformis in multiparous female successfully treated with oral cyclosporine. BMJ Case Rep 2011: bcr0220113915. - PMC - PubMed
    1. Oumeish OY, Parish JL. Impetigo herpetiformis. Clin Dermatol 2006; 24: 101–104. - PubMed
    1. Gambling D, Douglas MJ, McKay RSF (eds). Obstetric anesthesia and uncommon disorders. 2nd ed. Cambridge: Cambridge University Press, 2008, p.349.
    1. Patsatsi A, Theodoridis TD, et al. Cyclosporine in the management of impetigo herpetiformis: a case report and review of the literature. Case Rep Dermatol 2013; 5: 99–104. - PMC - PubMed

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