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. 2016 Apr-Jun;17(2):55-61.
doi: 10.4103/1995-705X.185114.

One Year Survival in Nigerians with Peripartum Cardiomyopathy

Kamilu M Karaye  1 , Krister Lindmark  2 , Michael Y Henein  2
Affiliations

One Year Survival in Nigerians with Peripartum Cardiomyopathy

Kamilu M Karaye et al. Heart Views. 2016 Apr-Jun.

Abstract

Background: Peripartum cardiomyopathy (PPCM) is common in North-Western Nigeria. This study aimed to describe the 1-year survival and left ventricular reverse remodeling (LVRR) in a group of patients with PPCM from three referral hospitals in Kano, Nigeria.

Methods: PPCM was defined according to recommendations of the Heart Failure (HF) Association of the European Society of Cardiology Working Group on PPCM. LVRR was defined as absolute increase in left ventricular ejection fraction (LVEF) by ≥10.0% and decrease in left ventricular (LV) end-diastolic dimension indexed to body surface area ≤33.0 mm/m(2), while recovered LV systolic function as LVEF ≥55%, at 12 months follow-up.

Results: A total of 54 newly diagnosed PPCM patients with mean age of 26.6 ± 6.7 years, presented with classical features of predominantly left-sided HF and 33 of them qualified for follow-up. Of the 17 survivors at 12 months, 8 patients (47.1%) satisfied the criteria for LVRR, of whom 5 (29.4%) had recovered LV systolic function (LVEF ≥55%), but LVRR was not predicted by any variable in the regression models. The prevalence of normal LV diastolic function increased from 11.1% at baseline to 35.3% at 12 months (P = 0.02). At 1-year follow-up, 41.4% of patients had died (two-thirds of them within the first 6 months), but mortality was not predicted by any variable including LVRR.

Conclusions: In Kano, PPCM patients had modest LVRR but high mortality at 1-year. Further studies should be carried out to identify reasons for the high mortality and how to curb it.

Keywords: Left ventricular reverse modeling; Nigeria; mortality; peripartum cardiomyopathy; survival.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Flowchart of recruitment and follow-up of patients
Figure 2
Figure 2
(a)Pattern of changes in left ventricular ejection fraction and end-diastolic dimension, left atrial dimension, and symptoms in peripartum cardiomyopathy patients over 1-year, (b) Pattern of changes in left ventricular diastolic dysfunction in peripartum cardiomyopathy patients over 1-year
See this image and copyright information in PMC

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