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Case Reports
. 2015 Dec;62(4):286-91.
doi: 10.1002/jmrs.143. Epub 2015 Oct 10.

Synchronous prostate and rectal adenocarcinomas irradiation utilising volumetric modulated arc therapy

Sweet Ping Ng  1 , Thu Tran  2 , Philip Moloney  2 , Charlotte Sale  2 , Maitham Mathlum  2 , Grace Ong  1 , Rod Lynch  2
Affiliations
Case Reports

Synchronous prostate and rectal adenocarcinomas irradiation utilising volumetric modulated arc therapy

Sweet Ping Ng et al. J Med Radiat Sci. 2015 Dec.

Abstract

Cases of synchronous prostate and colorectal adenocarcinomas have been sporadically reported. There are case reports on patients with synchronous prostate and rectal cancers treated with external beam radiotherapy alone or combined with high-dose rate brachytherapy boost to the prostate. Here, we illustrate a patient with synchronous prostate and rectal cancers treated using the volumetric arc therapy (VMAT) technique. The patient was treated with radical radiotherapy to 50.4 Gy in 28 fractions to the pelvis, incorporating the involved internal iliac node and the prostate. A boost of 24 Gy in 12 fractions was delivered to the prostate only, using VMAT. Treatment-related toxicities and follow-up prostate-specific antigen and carcinoembryonic antigen were collected for data analysis. At 12 months, the patient achieved complete response for both rectal and prostate cancers without significant treatment-related toxicities.

Keywords: Prostate; rectum; volumetric modulated arc technique.

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Figures

Figure 1
Figure 1
Dose distribution from the treatment planning system from Phase 1, Phase 2 and combined Phases 1 and 2 treatment.
Figure 2
Figure 2
Dose–volume histogram from combined Phases 1 and 2 treatments.
See this image and copyright information in PMC

References

    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet‐Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin 2015; 65: 87–108. - PubMed
    1. Qiu H, Herman JM, Ahuja N, Deweese TL, Song DY. Neoadjuvant chemoradiation followed by interstitial prostate brachytherapy for synchronous prostate and rectal cancer. Pract Radiat Oncol 2012; 2: e77–84. - PubMed
    1. Colonias A, Farinash L, Miller L, et al. Multidisciplinary treatment of synchronous primary rectal and prostate cancers. Nat Clin Pract Oncol 2005; 2: 271–4. - PubMed
    1. Klee LW, Grmoljez P. Combined radical retropubic prostatectomy and rectal resection. Urology 1999; 54: 679–81. - PubMed
    1. Ngan SY, Burmeister B, Fisher RJ, et al. Randomized trial of short‐course radiotherapy versus long‐course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: Trans‐Tasman Radiation Oncology Group trial 01.04. J Clin Oncol 2012; 30: 3827–33. - PubMed

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