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Case Reports
. 2016 Jul 7;7(Suppl 17):S488-91.
doi: 10.4103/2152-7806.185784. eCollection 2016.

Metastatic brain tumor from urothelial carcinoma of the prostatic urethra

Kohei Morita  1 , Masashi Oda  1 , Masaomi Koyanagi  1 , Masaaki Saiki  1
Affiliations
Case Reports

Metastatic brain tumor from urothelial carcinoma of the prostatic urethra

Kohei Morita et al. Surg Neurol Int. .

Abstract

Background: Urothelial carcinoma occurs in the bladder, upper urinary tract, and lower urinary tract, including prostatic urethra. A majority of the reported cases of intracranial metastasis from urothelial carcinoma originates from the bladder and upper urinary tract. Brain metastasis from urothelial carcinoma of the prostatic urethra has not yet been reported in the literature.

Case description: A 72-year-old male presented with a metastatic brain tumor and a 3-year history of urothelial carcinoma of the prostatic urethra treated with cystourethrectomy and chemotherapy with gemcitabine-cisplatin. Pathological diagnosis for tumor removal was compatible with metastatic brain tumor from urothelial carcinoma.

Conclusion: Brain metastasis from urothelial carcinoma of the prostatic urethra has not yet been reported in the literature. It is an extremely rare case, however, we should be careful of brain metastasis during follow-up for urothelial carcinoma in the lower urinary tract.

Keywords: Metastatic brain tumor; prostatic urethra; urothelial carcinoma.

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Figures

Figure 1
Figure 1
(a) A 68-year-old patient was treated with total cystourethrectomy. Hematoxylin-eosin staining of the prostatic urethra reveals urothelial carcinoma. The arrow indicates groups of urothelial carcinoma cells invading into the vein. (b) Hematoxylin-eosin staining of metastatic brain tumor shows groups of well-differentiated urothelial carcinoma cells with necrosis, which is the same pathological findings of the origin of the tumor, the prostatic urethra. The tumor was attached to the dura mater
Figure 2
Figure 2
(a) Magnetic resonance image (MRI) before the operation shows an irregularly shaped, heterogeneously enhanced mass with Gadolinium enhancement on T1 images. (b) MRI after the operation shows gross total removal of the tumor
See this image and copyright information in PMC

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