Comment
doi: 10.1016/j.chom.2016.07.013.
When Mr. Fap Meets the Gals
Affiliations
- PMID: 27512897
- DOI: 10.1016/j.chom.2016.07.013
Item in Clipboard
Comment
When Mr. Fap Meets the Gals
Cell Host Microbe.
.
Free article
Abstract
Fusobacteria are found to be overrepresented in the colorectal tumor microenvironment. In this issue of Cell Host & Microbe, Abed et al. (2016) describe a novel homing mechanism by which fusobacteria localize to tumors by recognizing a host polysaccharide (Gal-GalNAc) on cancer cells using a fusobacterial lectin, Fap2.
Copyright © 2016 Elsevier Inc. All rights reserved.
Comment on
-
Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc.Cell Host Microbe. 2016 Aug 10;20(2):215-25. doi: 10.1016/j.chom.2016.07.006. Cell Host Microbe. 2016. PMID: 27512904 Free PMC article.
Similar articles
-
Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc.Cell Host Microbe. 2016 Aug 10;20(2):215-25. doi: 10.1016/j.chom.2016.07.006. Cell Host Microbe. 2016. PMID: 27512904 Free PMC article.
-
Virulence factor discovery identifies associations between the Fic gene family and Fap2+ fusobacteria in colorectal cancer microbiomes.mBio. 2025 Feb 5;16(2):e0373224. doi: 10.1128/mbio.03732-24. Epub 2025 Jan 14. mBio. 2025. PMID: 39807864 Free PMC article.
-
Tumor Targeting by Fusobacterium nucleatum: A Pilot Study and Future Perspectives.Front Cell Infect Microbiol. 2017 Jun 30;7:295. doi: 10.3389/fcimb.2017.00295. eCollection 2017. Front Cell Infect Microbiol. 2017. PMID: 28713780 Free PMC article.
-
The emerging role of Fusobacteria in carcinogenesis.Eur J Clin Invest. 2024 Dec;54 Suppl 2(Suppl 2):e14353. doi: 10.1111/eci.14353. Eur J Clin Invest. 2024. PMID: 39674881 Free PMC article. Review.
-
Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy.Cancers (Basel). 2019 Oct 18;11(10):1592. doi: 10.3390/cancers11101592. Cancers (Basel). 2019. PMID: 31635333 Free PMC article. Review.
Cited by
-
Host mRNA Analysis of Periodontal Disease Patients Positive for Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia.Int J Mol Sci. 2022 Aug 31;23(17):9915. doi: 10.3390/ijms23179915. Int J Mol Sci. 2022. PMID: 36077312 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
