doi: 10.1128/AAC.33.5.788.
Efficacy of ciprofloxacin against Leptospira interrogans serogroup icterohaemorrhagiae
Affiliations
- PMID: 2751290
- PMCID: PMC172537
- DOI: 10.1128/AAC.33.5.788
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Efficacy of ciprofloxacin against Leptospira interrogans serogroup icterohaemorrhagiae
Antimicrob Agents Chemother.
1989 May.
Abstract
Ciprofloxacin activity against Leptospira interrogans serogroup icterohaemorrhagiae was studied in vitro and in an animal model. The MBC of ciprofloxacin was 0.6 microgram/ml. Three of three Syrian hamsters died 8 to 9 days after intraperitoneal challenge with 10(6) leptospires. In contrast, five of six animals given ciprofloxacin 3 or 5 days after challenge survived.
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