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Comment
. 2016 Aug 10;20(2):130-2.
doi: 10.1016/j.chom.2016.07.017.

NAGging Hexokinase PEPs up NLRP3

Henry Hampton  1 , Carolyn Hutcheon  1 , Naeha Subramanian  2
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NAGging Hexokinase PEPs up NLRP3

Henry Hampton et al. Cell Host Microbe. .
Free article

Abstract

Recognition of peptidoglycan is integral to detection of gram-positive bacterial pathogens. In a recent issue of Cell, Wolf et al. (2016) report that detection of the N-acetylglucosamine component of peptidoglycan by the glycolytic enzyme hexokinase activates the NLRP3 inflammasome, revealing an intriguing interplay between pathogen detection and metabolism.

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