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. 2016 Sep 2;18(17):4151-3.
doi: 10.1021/acs.orglett.6b01871. Epub 2016 Aug 11.

Method for Direct Synthesis of α-Cyanomethyl-β-dicarbonyl Compounds with Acetonitrile and 1,3-Dicarbonyls

Chenyang Wang  1 , Yabo Li  1 , Ming Gong  1 , Qi Wu  1 , Jianye Zhang  1 , Jung Keun Kim  1 , Mengmeng Huang  1 , Yangjie Wu  1
Affiliations

Method for Direct Synthesis of α-Cyanomethyl-β-dicarbonyl Compounds with Acetonitrile and 1,3-Dicarbonyls

Chenyang Wang et al. Org Lett. .

Abstract

A novel and efficient method for the synthesis of α-cyanomethyl-β-dicarbonyls in moderate to excellent yields is developed by using inactive CH3CN and simple 1,3-dicarbonyls. A radical mechanism is proposed under the ESI-MS (electrospray ionization mass spectrometry) analysis results of control experiments.

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