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Comment
. 2016 Sep;26(9):969-70.
doi: 10.1038/cr.2016.94. Epub 2016 Aug 12.

Mitochondrial fusion fuels T cell memory

Alessio Lanna  1 , Michael L Dustin  1
Affiliations
Comment

Mitochondrial fusion fuels T cell memory

Alessio Lanna et al. Cell Res. 2016 Sep.

Abstract

Differences in mitochondrial structures determine the metabolic landscape of effector and memory T cell populations in vivo.

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Figures

Figure 1
Figure 1
Accumulation of mitochondria at the immunological synapse. Electron tomography of immunological synapse formed on suppored lipid bilayers (SLB) containing ICAM-1 and agonist MHC peptide complexes. M, mitochondria; C, centriole; E, endosome; L, lysosome; S, secretory domain; RER, rough endoplasmic reticulum.
See this image and copyright information in PMC

Comment on

  • Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.
    Buck MD, O'Sullivan D, Klein Geltink RI, Curtis JD, Chang CH, Sanin DE, Qiu J, Kretz O, Braas D, van der Windt GJ, Chen Q, Huang SC, O'Neill CM, Edelson BT, Pearce EJ, Sesaki H, Huber TB, Rambold AS, Pearce EL. Buck MD, et al. Cell. 2016 Jun 30;166(1):63-76. doi: 10.1016/j.cell.2016.05.035. Epub 2016 Jun 9. Cell. 2016. PMID: 27293185 Free PMC article.

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