Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2016 Aug 6:8:61-2.
doi: 10.1016/j.eucr.2016.07.001. eCollection 2016 Sep.

Secondary or Transient Pseudohypoaldosteronism Associated With Urinary Tract Anomaly and Urinary Infection: A Case Report

Affiliations
Case Reports

Secondary or Transient Pseudohypoaldosteronism Associated With Urinary Tract Anomaly and Urinary Infection: A Case Report

Vinod Krishnappa et al. Urol Case Rep. .

Abstract

Hyponatremia with hyperkalemia in infancy is a rare presentation, but may be due to aldosterone deficiency or end organ resistance to its action. There are few cases associating this condition with urinary tract infections or anatomic abnormalities that predispose to infection. Clinicians should have a high index of suspicion in diagnosing secondary pseudohypoaldosteronism (PHA) due to its often atypical presentation. We describe ten month-old infant who presented with this condition and was found to have urinary tract infection complicating unilateral urinary tract anomaly, which may have strong association with renal tubular resistance to aldosterone.

Keywords: Hyperkalemia; Hyponatremia; Pseudohypoaldosteronism; Urinary tract anomalies; Urinary tract infections.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Renal ultrasonography showing duplicated left collecting system.

References

    1. Nandagopal R., Vaidyanathan P., Kaplowitz P. Transient pseudohypoaldosteronism due to urinary tract infection in infancy: a report of 4 cases. Int J Pediatr Endocrinol. 2009;2009:195728. - PMC - PubMed
    1. Geller D.S., Rodriguez-Soriano J., Vallo Boado A. Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I. Nat Genet. 1998;19:279–281. - PubMed
    1. Melzi M.L., Guez S., Sersale G. Acute pyelonephritis as a cause of hyponatremia/hyperkalemia in young infants with urinary tract malformations. Pediatr Infect Dis J. 1995;14:56–59. - PubMed
    1. Manikam L., Cornes M.P., Kalra D. Transient pseudohypoaldosteronism masquerading as congenital adrenal hyperplasia. Ann Clin Biochem. 2011;48:380–382. - PubMed
    1. Gerigk M., Glanzmann R., Rascher W. Hyponatraemia and hyperkalaemia in acute pyelonephritis without urinary tract anomalies. Eur J Pediatr. 1995;154:582–584. - PubMed

Publication types

LinkOut - more resources