Secondary or Transient Pseudohypoaldosteronism Associated With Urinary Tract Anomaly and Urinary Infection: A Case Report
- PMID: 27516976
- PMCID: PMC4976642
- DOI: 10.1016/j.eucr.2016.07.001
Secondary or Transient Pseudohypoaldosteronism Associated With Urinary Tract Anomaly and Urinary Infection: A Case Report
Abstract
Hyponatremia with hyperkalemia in infancy is a rare presentation, but may be due to aldosterone deficiency or end organ resistance to its action. There are few cases associating this condition with urinary tract infections or anatomic abnormalities that predispose to infection. Clinicians should have a high index of suspicion in diagnosing secondary pseudohypoaldosteronism (PHA) due to its often atypical presentation. We describe ten month-old infant who presented with this condition and was found to have urinary tract infection complicating unilateral urinary tract anomaly, which may have strong association with renal tubular resistance to aldosterone.
Keywords: Hyperkalemia; Hyponatremia; Pseudohypoaldosteronism; Urinary tract anomalies; Urinary tract infections.
Figures
References
-
- Geller D.S., Rodriguez-Soriano J., Vallo Boado A. Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I. Nat Genet. 1998;19:279–281. - PubMed
-
- Melzi M.L., Guez S., Sersale G. Acute pyelonephritis as a cause of hyponatremia/hyperkalemia in young infants with urinary tract malformations. Pediatr Infect Dis J. 1995;14:56–59. - PubMed
-
- Manikam L., Cornes M.P., Kalra D. Transient pseudohypoaldosteronism masquerading as congenital adrenal hyperplasia. Ann Clin Biochem. 2011;48:380–382. - PubMed
-
- Gerigk M., Glanzmann R., Rascher W. Hyponatraemia and hyperkalaemia in acute pyelonephritis without urinary tract anomalies. Eur J Pediatr. 1995;154:582–584. - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources