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. 2016 Sep 13;7(37):60193-60205.
doi: 10.18632/oncotarget.11173.

Site-specific associations between miRNA expression and survival in colorectal cancer cases

Martha L Slattery  1 , Jennifer S Herrick  1 , Daniel F Pellatt  1 , Lila E Mullany  1 , John R Stevens  2 , Erica Wolff  1 , Michael D Hoffman  1 , Roger K Wolff  1 , Wade Samowitz  3
Affiliations

Site-specific associations between miRNA expression and survival in colorectal cancer cases

Martha L Slattery et al. Oncotarget. .

Abstract

Background: MicroRNAs (miRNA) are small non-coding RNA involved in cellular processes, including cell proliferation and angiogenesis. Thus, miRNA expression may alter survival after diagnosis with colorectal cancer (CRC).

Results: Individuals diagnosed with stage 1 or stage 2 rectal cancer had worse survival than colon cancer cases diagnosed at stage 1 or stage 2. After adjustment for multiple comparisons, no miRNAs were significantly associated with disease stage. Two miRNAs infrequently expressed in the population and not previously reported were associated with survival after diagnosis with colon cancer (miR-1 HR 2.17 95% CI 1.41, 3.36; and miR-101-3p HR 3.51 95% CI 1.72, 7.15). Among those diagnosed with rectal cancer, 201 miRNAs were associated with survival when the FDR q value was < 0.05. Assessment of 105 previously reported miRNAs associated with prognosis showed that four miRNAs influenced colon cancer survival and 17 influenced survival after a diagnosis with rectal cancer when raw p values were considered.

Patients and methods: This study includes data from population-based studies of CRC conducted in Utah and the Kaiser Permanente Medical Care Program. A total of 1893 carcinoma and normal paired colorectal mucosa tissue samples were run using the Agilent Human miRNA Microarray V19.0. We assessed miRNA differential expression between paired carcinoma and normal colonic mucosa tissue with CRC- specific survival evaluating stage and site-specific associations after adjusting for age, sex, microsatellite instability tumor status, and AJCC stage.

Conclusions: MiRNAs dysregulated for both colon and rectal cancer had a greater impact on survival after a diagnosis with rectal cancer.

Keywords: colon cancer; disease stage; miRNA; rectal cancer.

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Conflict of interest statement

CONFLICTS OF INTEREST

None.

Figures

Figure 1
Figure 1. Kaplan meier plots of colon and rectal cancer survival by disease stage
See this image and copyright information in PMC

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