In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)

doi:10.3390/molecules21081045

. 2016 Aug 10;21(8):1045.

doi: 10.3390/molecules21081045.

In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)

Vivian Leliebre-Lara¹, Lianet Monzote Fidalgo², Eva-Maria Pferschy-Wenzig³, Olaf Kunert⁴, Clara Nogueiras Lima⁵, Rudolf Bauer⁶

Affiliations

¹ Centre for Natural Product Studies, Faculty of Chemistry, University of Havana, Zapata y G, La Habana 10400, Cuba. leliebre@fq.uh.cu.
² Parasitology Department, Institute of Tropical Medicine "Pedro Kouri" Marianao 13, Havana 10400, Cuba. monzote@ipk.sld.cu.
³ Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4, 8010 Graz, Austria. eva-maria.wenzig@uni-graz.at.
⁴ Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Universitaetsplatz 4, 8010 Graz, Austria. olaf.kunert@uni-graz.at.
⁵ Centre for Natural Product Studies, Faculty of Chemistry, University of Havana, Zapata y G, La Habana 10400, Cuba. clara@fq.uh.cu.
⁶ Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4, 8010 Graz, Austria. rudolf.bauer@uni-graz.at.

PMID: 27517895
PMCID: PMC6273698
DOI: 10.3390/molecules21081045

In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)

Vivian Leliebre-Lara et al. Molecules. 2016.

. 2016 Aug 10;21(8):1045.

doi: 10.3390/molecules21081045.

Authors

Vivian Leliebre-Lara¹, Lianet Monzote Fidalgo², Eva-Maria Pferschy-Wenzig³, Olaf Kunert⁴, Clara Nogueiras Lima⁵, Rudolf Bauer⁶

Affiliations

¹ Centre for Natural Product Studies, Faculty of Chemistry, University of Havana, Zapata y G, La Habana 10400, Cuba. leliebre@fq.uh.cu.
² Parasitology Department, Institute of Tropical Medicine "Pedro Kouri" Marianao 13, Havana 10400, Cuba. monzote@ipk.sld.cu.
³ Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4, 8010 Graz, Austria. eva-maria.wenzig@uni-graz.at.
⁴ Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Universitaetsplatz 4, 8010 Graz, Austria. olaf.kunert@uni-graz.at.
⁵ Centre for Natural Product Studies, Faculty of Chemistry, University of Havana, Zapata y G, La Habana 10400, Cuba. clara@fq.uh.cu.
⁶ Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4, 8010 Graz, Austria. rudolf.bauer@uni-graz.at.

PMID: 27517895
PMCID: PMC6273698
DOI: 10.3390/molecules21081045

Abstract

Two ergostanes, 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (1) and 5α-ergost-7,22-dien-3β-ol (2), and a lanostane, 3β-hydroxylanostan-8,24-diene-21-oic acid (trametenolic acid) (3), were isolated from an n-hexane extract prepared from the fruiting body of Trametes versicolor (Bres. Rivarden). The activity of the isolated sterols was evaluated against promastigotes and amastigotes of Leishmania amazonensis Lainson and Shaw, 1972. The lanostane, compound (3), showed the best inhibitory response (IC50 promastigotes 2.9 ± 0.1 μM and IC50 amastigotes 1.6 ± 0.1 μM). This effect was 25-fold higher compared with its cytotoxic effect on peritoneal macrophages from BALB/c mice. Therefore, trametenolic acid could be regarded as a promising lead for the synthesis of compounds with antileishmanial activity.

Keywords: Trametes versicolor; antileishmanial activity; trametenolic acid B.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

**Figure 1**
Chemical structure of sterols isolated from *Trametes versicolor* fruiting body. Ergosterol peroxide 1; 7,22-ergostadien-3β-ol 2 and trametenolic acid B 3.

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References

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[1] Singh N., Mishra B.B., Bajbai S., Singh R.K., Tiwari V.K. Natural product based leads to fight against leishmaniasis. Bioorg. Med. Chem. 2014;22:18–45. doi: 10.1016/j.bmc.2013.11.048. - DOI - PubMed

[2] Singh N., Mishra B.B., Bajbai S., Singh R.K., Tiwari V.K. Natural product based leads to fight against leishmaniasis. Bioorg. Med. Chem. 2014;22:18–45. doi: 10.1016/j.bmc.2013.11.048. - DOI - PubMed

[3] Alvar J., Vélez I.D., Bern C., Herrero Desjeux P., Cano J., Jannin J., den Boer M., The WHO Leishmaniasis Control Team Leishmaniasis worldwide and global estimates of its incidence. PLoS ONE. 2012;7:e35671. doi: 10.1371/journal.pone.0035671. - DOI - PMC - PubMed

[4] Alvar J., Vélez I.D., Bern C., Herrero Desjeux P., Cano J., Jannin J., den Boer M., The WHO Leishmaniasis Control Team Leishmaniasis worldwide and global estimates of its incidence. PLoS ONE. 2012;7:e35671. doi: 10.1371/journal.pone.0035671. - DOI - PMC - PubMed

[5] Copeland N.K., Aronson N.E. Leishmaniasis: Treatment updates and clinical practice guidelines review. Curr. Opin. Infect. Dis. 2015;28:426–437. doi: 10.1097/QCO.0000000000000194. - DOI - PubMed

[6] Copeland N.K., Aronson N.E. Leishmaniasis: Treatment updates and clinical practice guidelines review. Curr. Opin. Infect. Dis. 2015;28:426–437. doi: 10.1097/QCO.0000000000000194. - DOI - PubMed

[7] Sundar S., Rai M., Chakravarty J., Agarwal D., Agrawal N., Vaillant M., Olliaro P., Murray H.W. New treatment approach in Indian visceral leishmaniasis: Single-dose liposomal amphotericin B followed by short-course oral miltefosine. Clin. Infect. Dis. 2008;47:1000–1006. doi: 10.1086/591972. - DOI - PubMed

[8] Sundar S., Rai M., Chakravarty J., Agarwal D., Agrawal N., Vaillant M., Olliaro P., Murray H.W. New treatment approach in Indian visceral leishmaniasis: Single-dose liposomal amphotericin B followed by short-course oral miltefosine. Clin. Infect. Dis. 2008;47:1000–1006. doi: 10.1086/591972. - DOI - PubMed

[9] Berman J.D. Human Leishmaniasis: Clinical, diagnostic and chemotherapeutic developments in the last 10 years. Clin. Infect. Dis. 1997;24:684–703. doi: 10.1093/clind/24.4.684. - DOI - PubMed

[10] Berman J.D. Human Leishmaniasis: Clinical, diagnostic and chemotherapeutic developments in the last 10 years. Clin. Infect. Dis. 1997;24:684–703. doi: 10.1093/clind/24.4.684. - DOI - PubMed

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In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)

Affiliations

In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden)

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