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. 2016 Sep 2;18(17):4428-31.
doi: 10.1021/acs.orglett.6b02265. Epub 2016 Aug 12.

Cyanation of Phenol Derivatives with Aminoacetonitriles by Nickel Catalysis

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Cyanation of Phenol Derivatives with Aminoacetonitriles by Nickel Catalysis

Ryosuke Takise et al. Org Lett. .

Abstract

Generation of useful arylnitrile structures from simple aromatic feedstock chemicals represents a fundamentally important reaction in chemical synthesis. The first nickel-catalyzed cyanation of phenol derivatives with metal-free cyanating agents, aminoacetonitriles, is described. A nickel-based catalytic system consisting of a unique diphosphine ligand such as dcype or dcypt enables the cyanation of versatile phenol derivatives such as aryl carbamates and aryl pivalates. The use of aminoacetonitriles as a cyanating agent leads to an environmentally and easy-to-use method for arylnitrile synthesis.

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