Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Aug;6(3):16.
doi: 10.7603/s40681-016-0016-2. Epub 2016 Aug 13.

Association of different types of liver disease with demographic and clinical factors

Kao-Chi Cheng  1   2 , Wen-Yuan Lin  1   2 , Chiu-Shong Liu  1   2 , Cheng-Chieh Lin  1   2 , Hsueh-Chou Lai  3   4 , Shih-Wei Lai  5   6
Affiliations

Association of different types of liver disease with demographic and clinical factors

Kao-Chi Cheng et al. Biomedicine (Taipei). 2016 Aug.

Abstract

Background and aim: A metric that predicts the presence of cancer-related liver disease would allow early implementation of treatment. We compared the demographic and clinical characteristics of patients with no evidence of liver disease, with a cancer-associated liver disease, and with a liver disease not associated with cancer.

Methods: Retrospective, hospital-based, cross-sectional study which reviewed the medical records of subjects who underwent health examinations at a Taiwanese hospital from 2000 to 2004 and who had normal levels of amino transaminases. Demographic and clinical data were analyzed by univariate and multivariate statistics.

Results: A total of 2344 subjects had no evidence of liver disease (non-LD), and 1918 subjects had at least one liver disease (LD). The LD group was further divided into those with a cancer-associated liver disease (LD-1, n = 1632) and those with a liver disease not associated with cancer (LD-2, n = 286). Age, BMI, percentage of males, globulin:albumin ratio (G/A), percentage of patients with gallstones, AST, and ALT were significantly higher in the LD group. Univariate analysis showed that the G/A was significantly higher in the LD-2 group than the LD-1 group; multivariate analysis indicated that the G/A was not independently associated with liver disease, but that subjects who were older and had higher BMI were significantly more likely to have a cancer-associated liver disease.

Conclusions: For patients with liver disease, a multivariate model can be used to distinguish those with a cancer-associated liver disease from those with a liver disease not associated with cancer.

Keywords: Cirrhosis; Fatty liver; Globulin-albumin ratio; Hemangioma; Hepatitis; Liver cyst.

PubMed Disclaimer

Figures

Fig. 1 -
Fig. 1 -
Patient disposition
Fig. 2 -
Fig. 2 -
Predicted area under ROC curve (AUC) for the univariate model, which only considered G/A as an indicator of liver disease associated with cancer (LD-1) vs. liver disease not associated with cancer (LD-2).
Fig. 3 -
Fig. 3 -
Predicted area under ROC curve (AUC) for the multivariate model, which considered other confounding factors as indicators of liver disease associated with cancer (LD-1) vs. liver disease not associated with cancer (LD-2).
See this image and copyright information in PMC

References

    1. DiMarino AJ, editor. Sleisenger & Fordtran’s Gastrointestinal and Liver Disease. 8. Philadelphia: WB Saunders Co; 2006.
    1. Grant A, Neuberger J. Guidelines on the use of liver biopsy in clinical practice. Gut. 1999;45:1–11. doi: 10.1136/gut.45.2008.iv1. - DOI - PMC - PubMed
    1. Williams AL, Hoofnagle JH. Ratio of serum aspartate to alanine aminotransferase in chronic hepatits. Relationship to cirrhosis. Gastroenterology. 1988;95:734–9. - PubMed
    1. Sheth SG, Flamm SL, Gordon FD, Chopra S. AST/ALT ratio predicts cirrhosis in patients with chronic hepatitis C virus infection. Am. J Gastroenterol. 1998;93:44–8. - PubMed
    1. Luo JC, Hwang SJ, Chang FY, Chu CW, Lai CR, Wang YJ, et al. Simple blood tests can predict compensated liver cirrhosis in patients with chronic hepatitis C. Hepatogastroenterology. 2002;49:478–81. - PubMed

LinkOut - more resources