Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2016 Aug 4;375(5):494-6.
doi: 10.1056/NEJMc1600337.

Clinical Improvement with JAK2 Inhibition in Chuvash Polycythemia

Amy W Zhou  1 , Eric M Knoche  1 , Elizabeth K Engle  1 , Makiko Ban-Hoefen  2 , Charu Kaiwar  3 , Stephen T Oh  3
Affiliations
Case Reports

Clinical Improvement with JAK2 Inhibition in Chuvash Polycythemia

Amy W Zhou et al. N Engl J Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1. Patient Characteristics at Baseline and Clinical Response to Ruxolitinib in Three Patients with Chuvash Polycythemia
Panel A shows laboratory values, phlebotomy requirement, and symptoms for all three patients before treatment and during ruxolitinib therapy. ND denotes not determined. Panel B shows the effects of ruxolitinib on platelet-count oscillations in Patient CP-01 and the effects of ruxolitinib on hematocrit levels and phlebotomy requirements in Patients CP-02 and CP-03.
See this image and copyright information in PMC

References

    1. Poliakova LA. Familial erythrocytosis among the residents of the Chuvash ASSR. Probl Gematol Pereliv Krovi. 1974;19:30–33. (In Russian.) - PubMed
    1. Ang SO, Chen H, Hirota K, et al. Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia. Nat Genet. 2002;32:614–621. - PubMed
    1. Sergueeva AI, Miasnikova GY, Polyakova LA, Nouraie M, Prchal JT, Gordeuk VR. Complications in children and adolescents with Chuvash polycythemia. Blood. 2015;125:414–415. - PMC - PubMed
    1. Gordeuk VR, Prchal JT. Vascular complications in Chuvash polycythemia. Semin Thromb Hemost. 2006;32:289–294. - PubMed
    1. Russell RC, Sufan RI, Zhou B, et al. Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. Nat Med. 2011;17:845–853. - PMC - PubMed

Supplementary concepts