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. 1978 Oct;13(10):649-52.
doi: 10.1007/BF02533740.

Effect of catecholamines and β-blockers on linoleic acid desaturation activity

I N de Gómez Dumm  1 , M J de Alaniz  1 , R R Brenner  1
Affiliations

Effect of catecholamines and β-blockers on linoleic acid desaturation activity

I N de Gómez Dumm et al. Lipids. 1978 Oct.

Abstract

The effect of catecholamines and adrenergic blocking agents on the oxidative desaturation of linoleic acid in rat liver microsomes was studied. Epinephrine (1 mg/kg/body weight) produced a significant decrease on the conversion of [1-(14)C]linoleic acid to γ-linolenic acid. The effect of epinephrine was blocked by single injections of the β blockers propranolol (10 mg/kg body weight) or dichloroisoproterenol 30 min before the hormone treatment. Isoproterenol (100 μg/kg body weight) produced a significant decrease on the activity of the linoleyl-CoA desaturase. The effect of the catecholamines was postulated to be mediated through β receptors by an enhancement of the intracellular levels of cyclic AMP.

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References

    1. J Pharmacol Exp Ther. 1964 Jul;145:87-91 - PubMed
    1. J Lipid Res. 1972 Nov;13(6):783-9 - PubMed
    1. J Lipid Res. 1975 Jul;16(4):264-8 - PubMed
    1. J Pharmacol Exp Ther. 1972 Jun;181(3):479-88 - PubMed
    1. J Lipid Res. 1976 Nov;17(6):616-21 - PubMed

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