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. 2016 Nov;13(11):2128-2134.
doi: 10.1016/j.hrthm.2016.08.018. Epub 2016 Aug 9.

Adenosine testing during cryoballoon ablation and radiofrequency ablation of atrial fibrillation: A propensity score-matched analysis

Michifumi Tokuda  1 , Seiichiro Matsuo  2 , Ryota Isogai  2 , Goki Uno  2 , Kenichi Tokutake  2 , Kenichi Yokoyama  2 , Mika Kato  2 , Ryohsuke Narui  2 , Shinichi Tanigawa  2 , Seigo Yamashita  2 , Keiichi Inada  2 , Michihiro Yoshimura  2 , Teiichi Yamane  2
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Adenosine testing during cryoballoon ablation and radiofrequency ablation of atrial fibrillation: A propensity score-matched analysis

Michifumi Tokuda et al. Heart Rhythm. 2016 Nov.

Abstract

Background: The infusion of adenosine triphosphate after radiofrequency (RF) pulmonary vein (PV) isolation (PVI), which may result in acute transient PV-atrium reconnection, can unmask dormant conduction.

Objective: The purpose of this study was to compare the incidence and characteristics of dormant conduction after cryoballoon (CB) and RF ablation of atrial fibrillation (AF).

Methods: Of 414 consecutive patients undergoing initial catheter ablation of paroxysmal AF, 246 (59%) propensity score-matched patients (123 CB-PVI and 123 RF-PVI) were included.

Results: Dormant conduction was less frequently observed in patients who underwent CB-PVI than in those who underwent RF-PVI (4.5% vs 12.8% of all PVs; P < .0001). The incidence of dormant conduction in each PV was lower in patients who underwent CB-PVI than in those who underwent RF-PVI in the left superior PV (P < .0001) and right superior PV (P = .001). The site of dormant conduction was mainly located around the bottom of both inferior PVs after CB-PVI. Multivariable analysis revealed that a longer time to the elimination of the PV potential (odds ratio 1.018; 95% confidence interval 1.001-1.036; P = .04) and the necessity of touch-up ablation (odds ratio 3.242; 95% confidence interval 2.761-7.111; P < .0001) were independently associated with the presence of dormant conduction after CB-PVI. After the elimination of dormant conduction by additional ablation, the AF-free rate was similar in patients with and without dormant conduction after both CB-PVI and RF-PVI (P = .28 and P = .73, respectively).

Conclusion: The results of the propensity score-matched analysis showed that dormant PV conduction was less frequent after CB ablation than after RF ablation and was not associated with ablation outcomes.

Keywords: Ablation; Adenosine; Atrial fibrillation; Cryoballoon; Dormant conduction; Outcome; Pulmonary vein; Radiofrequency.

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