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. 2017 Jan;15(1):127-131.e2.
doi: 10.1016/j.cgh.2016.07.034. Epub 2016 Aug 12.

Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis

Ju Dong Yang  1 , Manal F Abdelmalek  2 , Cynthia D Guy  3 , Ryan M Gill  4 , Joel E Lavine  5 , Katherine Yates  6 , Jagpal Klair  7 , Norah A Terrault  8 , Jeanne M Clark  9 , Aynur Unalp-Arida  10 , Anna Mae Diehl  2 , Ayako Suzuki  11 ; Nonalcoholic Steatohepatitis Clinical Research Network
Collaborators, Affiliations

Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis

Ju Dong Yang et al. Clin Gastroenterol Hepatol. 2017 Jan.

Abstract

Background & aims: Sex and sex hormones can affect responses of patients with nonalcoholic fatty liver disease (NAFLD) to metabolic stress and development of hepatocyte injury and inflammation.

Methods: We collected data from 3 large U.S. studies of patients with NAFLD (between October 2004 and June 2013) to assess the association between histologic severity and sex, menopause status, synthetic hormone use, and menstrual abnormalities in 1112 patients with a histologic diagnosis of NAFLD. We performed logistic or ordinal logistic regression models, adjusting for covariates relevant to an increase of hepatic metabolic stress.

Results: Premenopausal women were at an increased risk of lobular inflammation, hepatocyte ballooning, and Mallory-Denk bodies than men and also at an increased risk of lobular inflammation and Mallory-Denk bodies than postmenopausal women (P < .01). Use of oral contraceptives was associated with an increased risk of lobular inflammation and Mallory-Denk bodies in premenopausal women, whereas hormone replacement therapy was associated with an increased risk of lobular inflammation in postmenopausal women (P < .05).

Conclusions: Being a premenopausal woman or a female user of synthetic hormones is associated with increased histologic severity of hepatocyte injury and inflammation among patients with NAFLD at given levels of hepatic metabolic stress.

Keywords: Fibrosis; Gender Differences; Risk Factor Analysis.

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Conflict of interest statement

The authors do not have conflict of interest related to this work.

Comment in

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