Molecular Pathology: Predictive, Prognostic, and Diagnostic Markers in Lymphoid Neoplasms

Abstract

Lymphoid neoplasms show great diversity in morphology, immunophenotypic profile, and postulated cells of origin, which also reflects the variety of genetic alterations within this group of tumors. This review discusses many of the currently known genetic alterations in selected mature B-cell and T-cell lymphoid neoplasms, and their significance as diagnostic, prognostic, and therapeutic markers. Given the rapidly increasing number of genetic alterations that have been described in this group of tumors, and that the clinical significance of many is still being studied, this is not an entirely exhaustive review of all of the genetic alterations that have been reported.

Keywords: B cell; Genetics; Lymphoma; Molecular marker; Mutation; Targeted therapy; T cell.