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. 2016:2016:2081962.
doi: 10.1155/2016/2081962. Epub 2016 Jul 21.

Comparison of the Effects of Glutamine, Curcumin, and Nesfatin-1 on the Gastric Serosal Surface Neomucosa Formation: An Experimental Rodent Model

Osman Bilgin Gulcicek  1 , Ali Solmaz  1 , Hakan Yiğitbaş  1 , Candas Ercetin  1 , Erkan Yavuz  1 , Kamil Ozdogan  1 , Sinan Arici  1 , Asli Kahraman Akkalp  2 , Tulin Sarac  3 , Fatih Çelebi  1 , Atilla Celik  1
Affiliations

Comparison of the Effects of Glutamine, Curcumin, and Nesfatin-1 on the Gastric Serosal Surface Neomucosa Formation: An Experimental Rodent Model

Osman Bilgin Gulcicek et al. Gastroenterol Res Pract. 2016.

Abstract

Introduction. Short bowel syndrome can crop up if more than 50% of small intestine is resected or when less than 100 cm of small bowel is left. Glutamine is the main food source of enterocytes. Curcumin has protective effects on intestinal ischemia-reperfusion damage. Nesfatin-1 is a satiety molecule. It has protective effects on gastric mucosa. The primary purpose of this study is to compare effects of glutamine, curcumin, and nesfatin-1 on the gastric serosal surface neomucosa formation on rats. Materials and Methods. 24 Wistar-Hannover rats were randomly divided into 4 groups and treated with saline, glutamine, curcumin, and nesfatin-1 after ileogastric anastomosis. After 14 days all rats were euthanized, and blood was collected. En bloc resection of anastomotic part was performed for histopathological examination. Results. PDGF, TGF-β, and VEGF levels and neomucosa formation were higher in glutamine group (p = 0.003, p = 0.003, and p = 0.025). Glutamine promotes the intestinal neomucosa formation on the gastric serosal surface and augments growth factors essential for neomucosa formation on rats. Conclusion. Glutamine may be used in short bowel syndrome for increasing the absorption surface area. But that needs to be determined by adequately powered clinical trials.

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Figures

Figure 1
Figure 1
Surgical procedure and histopathological assessment. ((a) and (b)) Anastomotic line is shown between the gastric surface and ileum on the postoperative 14th day. (c) Neomucosa formation on the gastric surface area.
Figure 2
Figure 2
Histological and morphologic evaluation. ((a) and (b)) Gastric mucosa, granulation tissue, and neomucosal tissue formation [hematoxylin and eosin (HE) ×110]. (c) Goblet cells and mucin in neomucosal surface [Alcian Blue (AB) ×220]. (d) Ulcer and granulation tissue in neomucosal surface [HE ×110]. (e) Fibroblastic activity in anastomotic line [Mason Trichrome ×110]. (f) Newly formed neomucosa and gastric mucosa [Alcian Blue ×110].
Figure 3
Figure 3
Ratio of neomucosa formation in groups (%).
See this image and copyright information in PMC

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