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Comparative Study
. 1989;24(4):230-2.
doi: 10.1007/BF00257623.

Evaluation of an amsacrine analog in a human tumor cloning system

B Lathan  1 , D D Von Hoff, G M Clark, E E Elslager
Affiliations
Comparative Study

Evaluation of an amsacrine analog in a human tumor cloning system

B Lathan et al. Cancer Chemother Pharmacol. 1989.

Abstract

A human tumor-cloning system was used to compare the antitumor activity of CI-921, a new amsacrine analog with that of its parent compound (amsacrine gluconate). A total of 48 specimens of 9 histologically different types of human malignancy were evaluable for a direct comparison of the cytotoxic activity. Both compounds were tested simultaneously at 10 micrograms/ml final concentration under continuous exposure. The overall activity was similar for both drugs, but the degree of cross-resistance was low. We concluded that in patients, CI-921 might have a different spectrum of antitumor activity from that of its parent compound.

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