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Case Reports
. 2016 Jul 20;4(8):816-9.
doi: 10.1002/ccr3.616. eCollection 2016 Aug.

GM-CSF as successful salvage therapy of metamizole (dipyrone)-induced agranulocytosis with Fournier's gangrene and severe septic shock in an adolescent

Annegret Winkler  1 , Silke Kietz  2 , Hagen Bahlmann  1 , Gunel Jafarzade  3 , Holger N Lode  2 , Matthias Heckmann  1
Affiliations
Case Reports

GM-CSF as successful salvage therapy of metamizole (dipyrone)-induced agranulocytosis with Fournier's gangrene and severe septic shock in an adolescent

Annegret Winkler et al. Clin Case Rep. .

Abstract

This case report describes the successful use of granulocyte and macrophage colony-stimulating factor as salvage therapy and an alternative to hematopoietic stem cell transplantation in a 14-year-old adolescent with metamizole (dipyrone)-induced agranulocytosis and severe septic shock.

Keywords: Agranulocytosis; filgrastim; metamizole (dipyrone); sargramostim; septic shock.

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Figures

Figure 1
Figure 1
Intraoperative findings on day 1. Left – the vulva and inguinal region after first debridement, right – sacral area with a lesion (10 cm × 5 cm × 5 cm) that extends down to the sacrum.
Figure 2
Figure 2
The counts of neutrophil granulocytes and monocytes over time in a 14‐year‐old adolescent with metamizole‐induced agranulocytosis and severe septic shock, treated with granulopoiesis‐stimulating factors.
See this image and copyright information in PMC

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