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. 2016 Aug 11:4:56.
doi: 10.1186/s40560-016-0178-8. eCollection 2016.

One-year resource utilisation, costs and quality of life in patients with acute respiratory distress syndrome (ARDS): secondary analysis of a randomised controlled trial

Joachim Marti  1 , Peter Hall  2 , Patrick Hamilton  3 , Sarah Lamb  4 , Chris McCabe  5 , Ranjit Lall  6 , Julie Darbyshire  7 , Duncan Young  7 , Claire Hulme  8
Affiliations

One-year resource utilisation, costs and quality of life in patients with acute respiratory distress syndrome (ARDS): secondary analysis of a randomised controlled trial

Joachim Marti et al. J Intensive Care. .

Abstract

Background: The long-term economic and quality-of-life outcomes of patients admitted to intensive care unit (ICU) with acute respiratory distress syndrome are not well understood. In this study, we investigate 1-year costs, survival and quality of life following ICU admission in patients who required mechanical ventilation for acute respiratory distress syndrome.

Methods: Economic analysis of data collected alongside a UK-based multi-centre randomised, controlled trial, aimed at comparing high-frequency oscillatory ventilation with conventional mechanical ventilation. The study included 795 critically ill patients admitted to ICU. Hospital costs were assessed using daily data. Post-hospital healthcare costs, patient out-of-pocket expenses, lost earnings of survivors and their carers and health-related quality of life were assessed using follow-up surveys.

Results: The mean cost of initial ICU stay was £26,857 (95 % CI £25,222-£28,491), and the average daily cost in ICU was £1738 (CI £1667-£1810). Following hospital discharge, the average 1-year cost among survivors was £7523 (CI £5692-£9354). The mean societal cost at 1 year was £44,077 (£41,168-£46,985), and the total societal cost divided by the number of 1-year survivors was £90,206. Survivors reported significantly lower health-related quality of life than the age- and sex-matched reference population, and this difference was more marked in younger patients.

Conclusions: Given the high costs and low health-related quality of life identified, there is significant scope for further research aimed at improving care in this in-need patient group.

Trial registration: ISRCTN10416500.

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Figures

Fig. 1
Fig. 1
Flow chart of study population
Fig. 2
Fig. 2
Kaplan-Meier survival plots at 12 months
See this image and copyright information in PMC

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