Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016:2016:7684364.
doi: 10.1155/2016/7684364. Epub 2016 Jul 25.

Mixed Adenoneuroendocrine Carcinoma Causing Colonic Intussusception

Marina Morais  1 , André Costa Pinho  1 , Ana Marques  2 , Joanne Lopes  2 , Alexandre Duarte  1 , Pedro Correia da Silva  1 , José Manuel Lopes  2 , J Costa Maia  1
Affiliations

Mixed Adenoneuroendocrine Carcinoma Causing Colonic Intussusception

Marina Morais et al. Case Rep Surg. 2016.

Abstract

Colonic intussusception is a rare cause of intestinal obstruction in adults and is caused by a malignant lesion in about 70% of cases. Early diagnosis and treatment are essential. We present a 64-year-old male patient with right colonic intussusception caused by a mixed adenoneuroendocrine carcinoma (MANEC), presenting as a giant pedunculated polyp (54 mm of largest diameter). The patient underwent right colectomy with primary anastomosis and adjuvant chemotherapy. The diagnosis of intussusception of the colon in adults is difficult because of its rarity and nonspecific clinical presentation. In this case, the cause was a rare histological type malignant tumor (MANEC).

PubMed Disclaimer

Figures

Figure 1
Figure 1
Abdominal CT (11/2012), intussusception of the right colon, proximal to the transverse colon and hepatic flexure.
Figure 2
Figure 2
Total colonoscopy (11/2012), intussusception of the right colon by a giant pedunculated lesion.
Figure 3
Figure 3
Surgery (01/2013), massive tumor of the hepatic flexure causing intussusception into the transverse colon and proximal distension.
Figure 4
Figure 4
Macroscopic features of colon MANEC: surgical specimen (a) and details of tumor before (b) and after (c) section.
Figure 5
Figure 5
MANEC. Adenocarcinoma component ((a) HE ×40) of MANEC with tubular ((b) HE ×200) features and of NEC component ((c) HE ×40 and (d) HE ×400) with solid nests of atypical cells.
Figure 6
Figure 6
NEC component displaying diffuse synaptophysin ((a) ×100), focal chromogranin ((b) ×200) and CD56 ((c) ×200) expression, and >20% Ki-67 index ((d) ×200) in tumor cells.
See this image and copyright information in PMC

References

    1. Yalamarthi S., Smith R. C. Adult intussusception: case reports and review of literature. Postgraduate Medical Journal. 2005;81(953):174–177. doi: 10.1136/pgmj.2004.022749. - DOI - PMC - PubMed
    1. Reijnen H. A. M., Joosten H. J. M., de Boer H. H. M. Diagnosis and treatment of adult intussusception. The American Journal of Surgery. 1989;158(1):25–28. doi: 10.1016/0002-9610(89)90309-7. - DOI - PubMed
    1. Harry M., McFarlane M., Plummer J. Adenocarcinoma of the colon: an uncommon cause of adult colonic intussusception. West Indian Medical Journal. 2011;60(3):372–373. - PubMed
    1. Lorenzi M., Iroatulam A. J. N., Vernillo R., et al. Adult colonic intussusception caused by malignant tumor of the transverse colon. American Surgeon. 1999;65(1):11–14. - PubMed
    1. Nagorney D. M., Sarr M. G., McIlrath D. C. Surgical management of intussusception in the adult. Annals of Surgery. 1981;193(2):230–236. doi: 10.1097/00000658-198102000-00019. - DOI - PMC - PubMed

LinkOut - more resources