Levonorgestrel in contraceptives and multipurpose prevention technologies: does this progestin increase HIV risk or interact with antiretrovirals?

Affiliations

¹ aGuttmacher Institute, New York City, New York bDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland cDepartment of Family Medicine, Boston University School of Medicine/Boston Medical Center, Boston, Massachusetts dDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Editorial

Chelsea B Polis et al. AIDS. 2016.

. 2016 Nov 13;30(17):2571-2576.

doi: 10.1097/QAD.0000000000001229.

¹ aGuttmacher Institute, New York City, New York bDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland cDepartment of Family Medicine, Boston University School of Medicine/Boston Medical Center, Boston, Massachusetts dDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

No abstract available

Comment on

An updated systematic review of epidemiological evidence on hormonal contraceptive methods and HIV acquisition in women.
Polis CB, Curtis KM, Hannaford PC, Phillips SJ, Chipato T, Kiarie JN, Westreich DJ, Steyn PS. Polis CB, et al. AIDS. 2016 Nov 13;30(17):2665-2683. doi: 10.1097/QAD.0000000000001228. AIDS. 2016. PMID: 27500670 Free PMC article.

1. Polis CB, Curtis KM, Hannaford PC, Phillips SJ, Chipato T, Kiarie JN, et al. Update on hormonal contraceptive methods and risk of HIV acquisition in women: a systematic review of epidemiological evidence, 2016. AIDS. 2016 in press. - PMC - PubMed
1. Kontula K, Paavonen T, Luukkainen T, Andersson LC. Binding of progestins to the glucocorticoid receptor. Correlation to their glucocorticoid-like effects on in vitro functions of human mononuclear leukocytes. Biochem Pharmacol. 1983;32(9):1511–8. - PubMed
1. Africander D, Verhoog N, Hapgood JP. Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception. Steroids. 2011;76(7):636–52. doi: 10.1016/j.steroids.2011.03.001. - DOI - PubMed
1. Friend DR. An update on multipurpose prevention technologies for the prevention of HIV transmission and pregnancy. Expert Opin Drug Deliv. 2016;13(4):533–45. doi: 10.1517/17425247.2016.1134485. - DOI - PubMed
1. Murphy K, Irvin SC, Herold BC. Research gaps in defining the biological link between HIV risk and hormonal contraception. Am J Reprod Immunol. 2014;72(2):228–35. doi: 10.1111/aji.12209. - DOI - PMC - PubMed