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Case Reports
. 1989 Aug;34(8):1290-3.
doi: 10.1007/BF01537281.

Amoxycillin/clavulanic acid (Augmentin)-induced intrahepatic cholestasis

J F Dowsett  1 , T Gillow, A Heagerty, M Radcliffe, R Toadi, I Isle, R C Russell
Affiliations
Case Reports

Amoxycillin/clavulanic acid (Augmentin)-induced intrahepatic cholestasis

J F Dowsett et al. Dig Dis Sci. 1989 Aug.

Abstract

A 75-year-old man developed a biopsy-proven, drug-induced intrahepatic cholestasis after use of amoxycillin trihydrate combined with the beta-lactam inhibitor potassium clavulanate (Augmentin). Cholestatic liver injury is an uncommonly recognized, probably immunologically based adverse reaction to therapy with penicillin and its derivatives.

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