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Review
. 2016:2016:7121580.
doi: 10.1155/2016/7121580. Epub 2016 Jul 27.

Mesenchymal Stem Cells and Myeloid Derived Suppressor Cells: Common Traits in Immune Regulation

Irina Lyadova Vladimirovna  1 , Ekaterina Sosunova  1 , Alexander Nikolaev  1 , Tatiana Nenasheva  1
Affiliations
Review

Mesenchymal Stem Cells and Myeloid Derived Suppressor Cells: Common Traits in Immune Regulation

Irina Lyadova Vladimirovna et al. J Immunol Res. 2016.

Abstract

To protect host against immune-mediated damage, immune responses are tightly regulated. The regulation of immune responses is mediated by various populations of mature immune cells, such as T regulatory cells and B regulatory cells, but also by immature cells of different origins. In this review, we discuss regulatory properties and mechanisms whereby two distinct populations of immature cells, mesenchymal stem cells, and myeloid derived suppressor cells mediate immune regulation, focusing on their similarities, discrepancies, and potential clinical applications.

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Figures

Figure 1
Figure 1
Main mediators utilized by MSCs and MDSCs to suppress T cell responses and their effects.
Figure 2
Figure 2
Cellular targets and modulatory effects of MSCs and MDSCs.
See this image and copyright information in PMC

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References

    1. Vignali D. A. A., Collison L. W., Workman C. J. How regulatory T cells work. Nature Reviews Immunology. 2008;8:523–532. doi: 10.1038/nri2343. - DOI - PMC - PubMed
    1. Benoist C., Mathis D. Treg cells, life history, and diversity. Cold Spring Harbor Perspectives in Biology. 2012;4(9)a007021 - PMC - PubMed
    1. Durand J., Chiffoleau E. B cells with regulatory properties in transplantation tolerance. World Journal of Transplantation. 2015;5(4):196–208. doi: 10.5500/wjt.v5.i4.196. - DOI - PMC - PubMed
    1. Liu J., Chen D., Nie G. D., Dai Z. CD8+CD122+ T-cells: a newly emerging regulator with central memory cell phenotypes. Frontiers in Immunology. 2015;6, article 494 doi: 10.3389/fimmu.2015.00494. - DOI - PMC - PubMed
    1. Najar M., Raicevic G., Fayyad-Kazan H., Bron D., Toungouz M., Lagneaux L. Mesenchymal stromal cells and immunomodulation: a gathering of regulatory immune cells. Cytotherapy. 2016;18(2):160–171. doi: 10.1016/j.jcyt.2015.10.011. - DOI - PubMed

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