[Transplantability and immunogenicity in mice of lymphoma Nk/Ly cells modified by concanavalin A and neuraminidase]

Abstract

The modifying effect of con A, Vibrio cholerae and non-Vibrio cholerae neuraminidase (VCN, NVCN) on the proliferative potential and immunogenicity of experimental lymphoma NK/Ly cells is shown in vitro and in vivo. The efficacy of immunization by the modified tumour cells of mice with transplantable lymphoma is evaluated. A considerable decrease in the proliferative potential of transplantability and a moderate increase in immunogenicity of Con A treated cells were determined in vitro. The high immunogenicity of VCN-modified cells was found within the limits of the studied immunologic parameters. However, the VCN-MTC immunotherapy had no advantages over Con A-MTC immunotherapy. It is found that the modifying effect of NVCN on a tumour cell is inferior to the effect of Con A and VCN.