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. 2016 Nov;100(5):431-436.
doi: 10.1002/cpt.450. Epub 2016 Sep 15.

Lysosomal solute carrier transporters gain momentum in research

B Bissa  1 , A M Beedle  2 , R Govindarajan  3   4
Affiliations

Lysosomal solute carrier transporters gain momentum in research

B Bissa et al. Clin Pharmacol Ther. 2016 Nov.

Abstract

Emerging evidence indicates that lysosome function extends beyond macromolecular degradation. Genetic and functional defects in components of the lysosomal transport machinery cause lysosomal storage disorders implicating the lysosomal solute carrier (SLC) transporters as essential to vital cell processes. The pathophysiology and therapeutic potential of lysosomal SLC transporters are highlighted here, focusing on recent discoveries in autophagic amino acid sensing (SLC38A9), phagocytic regulation in macrophages (SLC29A3, SLC15A3/A4), adenosine triphosphate (ATP) exocytosis in neurotransmission (SLC17A9), and lysosomal transport of maytansine catabolites into the cytoplasm (SLC46A3).

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
A schematic model of the lysosomal solute carrier (SLC)ome: emerging roles in cellular pathophysiology and pharmacology. A multitude of lysosomal SLCs across lysosomal membrane is involved in the lysosomal transport of solutes. Significant advances in understanding the lysosome proteome has revealed novel roles for lysosomal SLCs, including SLC38A9 as an amino acid sensor (by direct interaction with mTOR complex), SLC17A9 as a mediator of adenosine triphosphate (ATP) exocytosis, SLC15A3/A4 as a participant in toll‐like receptor (TLR) signaling, SLC29A3 as a regulator of nucleoside salvage, and SLC46A3 as a facilitator of antibody‐drug conjugate maytansine efflux. mTOR, mammalian target of Rapamycin; RagA, Ragulator A; RagC, Ragulator C.
See this image and copyright information in PMC

References

    1. Wang, S. et al Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science 347, 188–194 (2015). - PMC - PubMed
    1. Nakamura, N. et al Endosomes are specialized platforms for bacterial sensing and NOD2 signalling. Nature 509, 240–244 (2014). - PubMed
    1. Hsu C.L. et al Equilibrative nucleoside transporter 3 deficiency perturbs lysosome function and macrophage homeostasis. Science 335, 89–92 (2012). - PubMed
    1. Ho, T. et al Vesicular expression and release of ATP from dopaminergic neurons of the mouse retina and midbrain. Front. Cell. Neurosci. 9, 389 (2015). - PMC - PubMed
    1. Hamblett, K.J. et al SLC46A3 is required to transport catabolites of noncleavable antibody maytansine conjugates from the lysosome to the cytoplasm. Cancer Res. 75, 5329–5340 (2015). - PubMed

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