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Review
. 2016 Nov;49(11):607-611.
doi: 10.5483/bmbrep.2016.49.11.145.

Exploring cancer genomic data from the cancer genome atlas project

Ju-Seog Lee  1
Affiliations
Review

Exploring cancer genomic data from the cancer genome atlas project

Ju-Seog Lee. BMB Rep. 2016 Nov.

Abstract

The Cancer Genome Atlas (TCGA) has compiled genomic, epigenomic, and proteomic data from more than 10,000 samples derived from 33 types of cancer, aiming to improve our understanding of the molecular basis of cancer development. Availability of these genome-wide information provides an unprecedented opportunity for uncovering new key regulators of signaling pathways or new roles of pre-existing members in pathways. To take advantage of the advancement, it will be necessary to learn systematic approaches that can help to uncover novel genes reflecting genetic alterations, prognosis, or response to treatments. This minireview describes the updated status of TCGA project and explains how to use TCGA data. [BMB Reports 2016; 49(11): 607-611].

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Figures

Fig. 1
Fig. 1
Visualization of analyzed data. (A) The spectrum of genetic alteration in PRDX genes in different cancer types. (B) Genetic alterations of PRDX genes in ovarian cancer. (C) Kaplan-Meier plot of patients with ovarian cancer stratified according to genetic alteration of PRDX genes.
Fig. 2
Fig. 2
Scatter plots between mRNA expression and copy number alteration of PRDX1 and PRDX2 in ovarian cancer.
See this image and copyright information in PMC

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