Increased PI3K/Akt activity and deregulated humoral immune response in human PTEN deficiency

Affiliations

¹ Department of Pediatric Infectious Disease and Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
² Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
³ Deparment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
⁴ Department of Women and Children Health, Division of Pediatrics, University of Padova, Padova, Italy.
⁵ Faculty of Medicine, Department of Pediatrics, Division of Genetics, Ege University, Izmir, Turkey.
⁶ Juliana Children's Hospital, Den Haag, The Netherlands.
⁷ Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Freiburg, Germany.
⁸ Faculty of Medicine, Department of Pediatrics, Division of Pediatric Immunology, Ege University, Izmir, Turkey.
⁹ Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Electronic address: m.vanderburg@erasmusmc.nl.

Case Reports

Gertjan J Driessen et al. J Allergy Clin Immunol. 2016 Dec.

. 2016 Dec;138(6):1744-1747.e5.

doi: 10.1016/j.jaci.2016.07.010. Epub 2016 Aug 13.

¹ Department of Pediatric Infectious Disease and Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
² Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
³ Deparment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
⁴ Department of Women and Children Health, Division of Pediatrics, University of Padova, Padova, Italy.
⁵ Faculty of Medicine, Department of Pediatrics, Division of Genetics, Ege University, Izmir, Turkey.
⁶ Juliana Children's Hospital, Den Haag, The Netherlands.
⁷ Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Freiburg, Germany.
⁸ Faculty of Medicine, Department of Pediatrics, Division of Pediatric Immunology, Ege University, Izmir, Turkey.
⁹ Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Electronic address: m.vanderburg@erasmusmc.nl.

No abstract available

Publication types