Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Dec;12(12):3160-3165.
doi: 10.1080/21645515.2016.1216286.

A review of immunogenicity and tolerability of live attenuated Hepatitis A vaccine in children

Sameer Rao  1 , J S Mao  2 , Salman Motlekar  1 , Zhuang Fangcheng  2 , Ganesh Kadhe  1
Affiliations
Review

A review of immunogenicity and tolerability of live attenuated Hepatitis A vaccine in children

Sameer Rao et al. Hum Vaccin Immunother. 2016 Dec.

Abstract

Changing epidemiology of Hepatitis A virus (HAV) has led to an increased susceptibility of adolescents and adults to the infection. Vaccination can remarkably reduce the incidence and associated morbidity of HAV infection. This review is focused on the safety and efficacy of H2 strain derived live attenuated Hepatitis A vaccine. We found the vaccine to be highly immunogenic with minimal or negligible safety issues. Moreover, a single dose of live attenuated vaccine persists a long term immune response and can be a preferred option for developing countries. In 2014, Indian Academy of Paediatrics (IAP) also updated their recommendations for H2 vaccine as a single dose as against the previous 2 dose schedule. A focused approach to include the vaccine in national immunization program should be explored.

Keywords: Hepatitis A; immunogenicity; live attenuated vaccine; safety; seroconversion.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Sero-protective rate (%) across China and India as reported in different studies.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Krugman S. The gordon Wilson lecture. The ABC's of viral hepatitis. Trans Am Clin Climatol Assoc 1992; 103:145-56; PMID:1413374 - PMC - PubMed
    1. Costa-Mattioli M, Di Napoli A, Ferre V, Billaudel S, Perez-Bercoff R, Cristina J. Genetic variability of hepatitis A virus. J Gen Virol 2003; 84:3191-201; PMID:14645901; http://dx.doi.org/10.1099/vir.0.19532-0 - DOI - PubMed
    1. Koff RS. Hepatitis A. Lancet 1998; 351:1643-9; PMID:9620732; http://dx.doi.org/10.1016/S0140-6736(98)01304-X - DOI - PubMed
    1. Hadler SC, McFarland L. Hepatitis in day care centers: epidemiology and prevention. Rev Infect Dis 1986; 8:548-57; PMID:3018889; http://dx.doi.org/10.1093/clinids/8.4.548 - DOI - PubMed
    1. Jacobsen KH. The global prevalence of Hepatitis A virus infection and susceptibility: a systematic review. 2010. Available at: http://apps.who.int/iris/bitstream/10665/70180/1/WHO_IVB_10.01_eng.pdf; Accessed on August 10, 2016.