Cytosolic DNA Sensing: The Field Narrows
- PMID: 27533006
- DOI: 10.1016/j.immuni.2016.08.006
Cytosolic DNA Sensing: The Field Narrows
Abstract
The innate response to many pathogens involves type I interferon production that is initiated upon cytosolic detection of double-stranded DNA (dsDNA), but how dsDNA is detected is controversial. In this issue of Immunity, Gray et al. (2016) use genetics to bring some much-needed clarity to the field.
Copyright © 2016 Elsevier Inc. All rights reserved.
Comment on
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The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA.Immunity. 2016 Aug 16;45(2):255-66. doi: 10.1016/j.immuni.2016.06.015. Epub 2016 Aug 2. Immunity. 2016. PMID: 27496731 Free PMC article.
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