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Comment
. 2016 Aug 16;45(2):227-8.
doi: 10.1016/j.immuni.2016.08.006.

Cytosolic DNA Sensing: The Field Narrows

Russell E Vance  1
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Cytosolic DNA Sensing: The Field Narrows

Russell E Vance. Immunity. .
Free article

Abstract

The innate response to many pathogens involves type I interferon production that is initiated upon cytosolic detection of double-stranded DNA (dsDNA), but how dsDNA is detected is controversial. In this issue of Immunity, Gray et al. (2016) use genetics to bring some much-needed clarity to the field.

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