PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria
- PMID: 27533008
- DOI: 10.1016/j.immuni.2016.08.001
PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria
Abstract
How early interactions between innate and adaptive immune cells influence outcomes of acute infections is incompletely understood. In this issue of Immunity, Karunarathne et al. (2016) show that dendritic cells help CD4(+) T helper 1 cell immunity against malaria through PD-L2's competition with PD-L1.
Published by Elsevier Inc.
Comment on
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Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity.Immunity. 2016 Aug 16;45(2):333-45. doi: 10.1016/j.immuni.2016.07.017. Immunity. 2016. PMID: 27533014
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