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. 2016 Aug 16;45(2):233-5.
doi: 10.1016/j.immuni.2016.07.024.

Feeling Worn Out? PGC1α to the Rescue for Dysfunctional Mitochondria in T Cell Exhaustion

Maria L Balmer  1 , Christoph Hess  2
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Feeling Worn Out? PGC1α to the Rescue for Dysfunctional Mitochondria in T Cell Exhaustion

Maria L Balmer et al. Immunity. .
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Abstract

In chronic viral infections and cancer, T cells acquire a functional state characterized by reduced effector functionality, termed exhaustion. In two related studies by Scharping et al. (2016) and Bengsch et al. (2016) in this issue of Immunity, dysfunctional mitochondria are identified as a key correlate of CD8(+) T cell exhaustion.

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