Cancer: Suffocation of gene expression
- PMID: 27533033
- DOI: 10.1038/nature19426
Cancer: Suffocation of gene expression
Comment on
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Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.Cell. 2009 Mar 6;136(5):839-851. doi: 10.1016/j.cell.2009.01.020. Epub 2009 Feb 12. Cell. 2009. PMID: 19217150 Free PMC article.
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Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene.Br J Cancer. 2010 Jan 19;102(2):428-35. doi: 10.1038/sj.bjc.6605450. Br J Cancer. 2010. PMID: 20087356 Free PMC article.
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Tumour hypoxia causes DNA hypermethylation by reducing TET activity.Nature. 2016 Sep 1;537(7618):63-68. doi: 10.1038/nature19081. Epub 2016 Aug 17. Nature. 2016. PMID: 27533040 Free PMC article.
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