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. 2012 Mar 5;1(1):55-64.
doi: 10.3109/21556660.2012.672353. eCollection 2012.

The role of the renin-angiotensin system blocking in the management of atrial fibrillation

Brett Cliff  1 , Naveed Younis  2 , Salam Hama  3 , Handrean Soran  4
Affiliations

The role of the renin-angiotensin system blocking in the management of atrial fibrillation

Brett Cliff et al. J Drug Assess. .

Abstract

Objective: To review current available evidence for the role of renin-angiotensin system blockade in the management of atrial fibrillation.

Method: We conducted a PubMed and Medline literature search (January 1980 through July 2011) to identify all clinical trials published in English concerning the use of angiotensin converting enzyme inhibitors or angiotensin II receptor blockers for primary and secondary prevention of atrial fibrillation. We also discussed renin-angiotensin system and its effects on cellular electrophysiology.

Conclusion: The evidence from the current studies discussed does not provide a firm definitive indication for the use of angiotensin converting enzyme inhibitors or angiotensin II receptor blockers in the primary or secondary prevention of atrial fibrillation. Nevertheless, modest benefits were observed in patients with left ventricular dysfunction. In view of the possible benefits and the low incidence of side-effects with angiotensin converting enzyme inhibitors and angiotensin II receptor blockers, they can be given to patients with recurrent AF, specifically those with hypertension, heart failure and diabetes mellitus.

Keywords: Angiotensin II receptor blockers; Angiotensin converting enzyme inhibitors; Atrial fibrillation; Renin–angiotensin system.

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Figure 1.
Figure 1.
Renin–angiotensin system.
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