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Review
. 2016 Aug 18;10(8):e0004572.
doi: 10.1371/journal.pntd.0004572. eCollection 2016 Aug.

The Case for Live Attenuated Vaccines against the Neglected Zoonotic Diseases Brucellosis and Bovine Tuberculosis

Aseem Pandey  1   2   3 , Ana Cabello  2 , Lavoisier Akoolo  2 , Allison Rice-Ficht  2   4 , Angela Arenas-Gamboa  2 , David McMurray  1 , Thomas A Ficht  2 , Paul de Figueiredo  1   2   3
Affiliations
Review

The Case for Live Attenuated Vaccines against the Neglected Zoonotic Diseases Brucellosis and Bovine Tuberculosis

Aseem Pandey et al. PLoS Negl Trop Dis. .

Abstract

Vaccination of humans and animals with live attenuated organisms has proven to be an effective means of combatting some important infectious diseases. In fact, the 20th century witnessed tremendous improvements in human and animal health worldwide as a consequence of large-scale vaccination programs with live attenuated vaccines (LAVs). Here, we use the neglected zoonotic diseases brucellosis and bovine tuberculosis (BTb) caused by Brucella spp. and Mycobacterium bovis (M. bovis), respectively, as comparative models to outline the merits of LAV platforms with emphasis on molecular strategies that have been pursued to generate LAVs with enhanced vaccine safety and efficacy profiles. Finally, we discuss the prospects of LAV platforms in the fight against brucellosis and BTb and outline new avenues for future research towards developing effective vaccines using LAV platforms.

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Conflict of interest statement

The authors have declared that no competing interests exist.

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