Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2016 Oct;175(2):187-188.
doi: 10.1111/bjh.14299. Epub 2016 Aug 19.

Substance P and sickle cell disease-a marker for pain and novel therapeutic approaches

Steven D Douglas  1
Affiliations
Editorial

Substance P and sickle cell disease-a marker for pain and novel therapeutic approaches

Steven D Douglas. Br J Haematol. 2016 Oct.
No abstract available

Keywords: aprepitant; neurokinin 1 antagonist; pain; sickle cell disease; substance P.

PubMed Disclaimer

Comment on

References

    1. Ballas SK, Gupta K, Adams-Graves P. Sickle cell pain: a critical reappraisal. Blood. 2012;120(18):3647–3656. - PubMed
    1. Barret JS, Spitsin S, Moorthy G, Barrett K, Baker K, Lackner A, Tuluc F, Winters A, Evans DL, Douglas SD. Pharmacologic rationale for the NK1R antagonist, aprepitant, as adjunctive therapy in HIV. Journal of Translational Medicine. 2016;14(1):148–162. - PMC - PubMed
    1. Brandow A, Farley R, Panepinto J. Early insights Into the Neurobiology of Pain in Sickle Cell Disease: A Systematic Review of the Literature. Pediatric Blood Cancer. 2015;62:1501–1511. - PMC - PubMed
    1. Brandow A, Wandersee N, Dasgupta M, Hoffmann R, Hillery C, Stucky C, Panepinto J. Substance P is increased in patients with sickle cell disease and associated with hemolysis and hydroxycarbamide use. British Journal of Hematology 2016 this issue. - PMC - PubMed
    1. Douglas SD, Leeman SE. Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation. Ann NY Acad Sci. 2011;1217:83–95. - PMC - PubMed

LinkOut - more resources