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Review
. 2016 Aug 19:22:2917-23.
doi: 10.12659/msm.896557.

Transient Receptor Potential Ankyrin 1 (TRPA1) Channel and Neurogenic Inflammation in Pathogenesis of Asthma

Hang Yang  1 , ShuZhuang Li  1
Affiliations
Review

Transient Receptor Potential Ankyrin 1 (TRPA1) Channel and Neurogenic Inflammation in Pathogenesis of Asthma

Hang Yang et al. Med Sci Monit. .

Abstract

Asthma is characterized by airway inflammation, airway obstruction, and airway hyperresponsiveness (AHR), and it affects 300 million people worldwide. However, our current understanding of the molecular mechanisms that underlie asthma remains limited. Recent studies have suggested that transient receptor potential ankyrin 1 (TRPA1), one of the transient receptor potential cation channels, may be involved in airway inflammation in asthma. The present review discusses the relationship between TRPA1 and neurogenic inflammation in asthma, hoping to enhance our understanding of the mechanisms of airway inflammation in asthma.

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Figures

Figure 1
Figure 1
Schematic representation of the mechanisms of neurogenic inflammation.
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