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. 2017 Jan;16(1):91-97.
doi: 10.1016/j.jcf.2016.07.011. Epub 2016 Aug 15.

Cancer risk among lung transplant recipients with cystic fibrosis

Aliza K Fink  1 , Elizabeth L Yanik  2 , Bruce C Marshall  3 , Michael Wilschanski  4 , Charles F Lynch  5 , April A Austin  6 , Glenn Copeland  7 , Mahboobeh Safaeian  2 , Eric A Engels  2
Affiliations

Cancer risk among lung transplant recipients with cystic fibrosis

Aliza K Fink et al. J Cyst Fibros. 2017 Jan.

Abstract

Background: Previous studies demonstrated increased digestive tract cancers among individuals with cystic fibrosis (CF), particularly among lung transplant recipients. We describe cancer incidence among CF and non-CF lung recipients.

Methods: We used data from the US transplant registry and 16 cancer registries. Standardized incidence ratios (SIRs) compared cancer incidence to the general population, and competing risk methods were used for the cumulative incidence of colorectal cancer.

Results: We evaluated 10,179 lung recipients (1681 with CF). Risk was more strongly increased in CF recipients than non-CF recipients for overall cancer (SIR 9.9 vs. 2.7) and multiple cancers including colorectal cancer (24.2 vs. 1.7), esophageal cancer (56.3 vs. 1.3), and non-Hodgkin lymphoma (61.8 vs. 9.4). At five years post-transplant, colorectal cancer was diagnosed in 0.3% of CF recipients aged <50 at transplant and 6.4% aged ≥50.

Conclusions: CF recipients have increased risk for colorectal cancer, suggesting a need for enhanced screening.

Keywords: Cancer; Transplant.

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Figures

Figure 1:
Figure 1:. Standardized Incidence Ratios for Selected Cancers among CF and Non-CF Lung Recipients
The figure shows standardized incidence ratios (circles) and 95% confidence intervals (vertical lines) among lung recipients with and without cystic fibrosis (CF). Results are shown for cancer for which there was at least 1 observed case among recipients with CF. Cancers for which the SIR for CF recipients is statistically significantly different from the SIR for non-CF recipients are marked by a ★
Figure 2:
Figure 2:. Standardized Incidence Ratios of Colorectal Cancer for CF and Non-CF Lung Recipients, by Colorectal Subsite
The figure shows standardized incidence ratios (circles) and 95% confidence intervals (vertical lines) among lung recipients with and without cystic fibrosis (CF). Results are shown for colorectal cancer overall and for cancers arising in colorectal subsites
Figure 3:
Figure 3:. Cumulative Incidence of Colorectal Cancer in Lung Recipients, by CF Status and Age at Transplant
The figure shows the cumulative incidence of colorectal cancer among lung recipients according to reason for transplant and age at transplant. Black lines correspond to estimates for recipients with cystic fibrosis (CF) and gray lines correspond to estimates for recipients without CF.
See this image and copyright information in PMC

References

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