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. 2016 Aug 18;63(4):542-544.
doi: 10.1016/j.molcel.2016.08.006.

DNA Polymerase θ: Duct Tape and Zip Ties for a Fragile Genome

Nicholas A Willis  1 , Ralph Scully  2
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DNA Polymerase θ: Duct Tape and Zip Ties for a Fragile Genome

Nicholas A Willis et al. Mol Cell. .
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Abstract

Using a combination of genetics and cellular DNA rejoining assays, in this issue of Molecular Cell, Wyatt et al. (2016) demonstrate a critical role for mammalian DNA polymerase θ in the rejoining of DNA ends that are poor substrates for classical non-homologous end joining.

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