Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jul 14;53(4):1641-52.
doi: 10.3233/JAD-160365.

Neuritic and Diffuse Plaque Associations with Memory in Non-Cognitively Impaired Elderly

Michael Malek-Ahmadi  1 , Sylvia E Perez  2 , Kewei Chen  1 , Elliott J Mufson  2   3
Affiliations

Neuritic and Diffuse Plaque Associations with Memory in Non-Cognitively Impaired Elderly

Michael Malek-Ahmadi et al. J Alzheimers Dis. .

Abstract

The presence of Alzheimer's disease (AD)-related neuropathology among cognitively normal individuals has been well documented. It has been proposed that these individuals may represent a pre-clinical AD population. Previous studies have demonstrated a negative association between the presence of both amyloid-β (Aβ) plaques and neurofibrillary tangles with ante-mortem cognitive performance, a relationship which is likely influenced by a number of factors including age and APOE ɛ4 carrier status. The present study determined whether the presence of neuritic plaques (NPs) and diffuse plaques (DPs) are associated with performance in a number of cognitive domains after accounting for APOE ɛ4 carrier status and neurofibrillary tangle presence in a cohort of 123 older participants from the Rush Religious Order Study who died with a premortem clinical diagnosis of no cognitive impairment (NCI). After adjusting for age at death, education, gender, Braak stage, and APOE ɛ4 carrier status, the presence of NPs was associated with lower performance in the cognitive domains of Global Cognition (p = 0.002), Episodic Memory (p = 0.03), Semantic Memory (p = 0.009), and Visuospatial performance (p = 0.006), while DPs showed no association with any cognitive domain examined. These results suggest that decreases in cognition in elderly NCI individuals are associated with an increase in NPs and not DPs when age at death, education, gender, APOE ɛ4 status, and Braak stage are taken into consideration.

Keywords: Amyloid-β; Braak stage; cognition; neuropathology; pre-clinical Alzheimer’s disease.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Cognitive domain differences for neuritic (A) and diffuse (B) plaques. ∗p ≤ 0.05.
Fig. 2.
Fig. 2.
Correlation of Braak stage with total neuritic (A) and total diffuse (B) plaque scores.
Fig. 3.
Fig. 3.
Total diffuse and neuritic plaque scores by Braak stage. ∗p ≤ 0.05 for neuritic versus diffuse in each Braak stage.
See this image and copyright information in PMC

References

    1. Tomlinson BE, Blessed G, Roth M (1968) Observations on the brains of non-demented old people. J Neurol Sci 7, 331–356. - PubMed
    1. Bennett DA, Schneider JA, Arvanitakis Z, Kelly JF, Aggarwal NT, Shah RC, Wilson RS (2006) Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology 66, 1837–1844. - PubMed
    1. Dickson DW, Crystal HA, Mattiace LA, Masur DM, Blau AD, Davies P, Yen SH, Aronson MK (1992) Identification of normal and pathological aging in prospectively studied nondemented elderly humans. Neurobiol Aging 13, 179–189. - PubMed
    1. Mormino EC (2014) The relevance of beta-amyloid on markers of Alzheimer’s disease in clinically normal individuals and factors that influence these associations. Neuropsychol Rev 24, 300–312. - PMC - PubMed
    1. Morris JC, Storandt M, McKeel DW Jr, Rubin EH, Price JL, Grant EA, Berg L (1996) Cerebral amyloid deposition and diffuse plaques in “normal” aging: Evidence for presympomatic and very mild Alzheimer’s disease. Neurology 46, 707–719. - PubMed

Publication types

Substances