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Comment
. 2016 Sep;100(9):1789-1790.
doi: 10.1097/TP.0000000000001429.

Blurring the Lines Between Innate and Adaptive Immunity

Nicholas Chun #  1 , Peter S Heeger #  1
Affiliations
Comment

Blurring the Lines Between Innate and Adaptive Immunity

Nicholas Chun et al. Transplantation. 2016 Sep.
No abstract available

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Figures

Figure 1
Figure 1
Effects of immune cell-derived complement on T cell immune responses. TCR ligation in addition to costimulation results in immune cell production and local activation of alternative pathway complement components. Subsequently, C3a/Cs5a bind to their surface receptors expressed on a) T cells, initiating proliferative and survival signals, and b) on APCs, inducing upregulation of costimulatory molecules and release of innate cytokines. TCR ligation plus crosslinking of CD46 activates human T cell intrinsic inflammasomes via signaling that likely depends on intracellular formation of C5a. Inflammasome activation on T cells, in turn, enhances IFNγ production and Th1 differentiation.
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References

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