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Comparative Study
. 2016 Oct 4;7(40):65024-65033.
doi: 10.18632/oncotarget.11344.

Luminal B breast cancer: patterns of recurrence and clinical outcome

Zhi-Hua Li  1 , Ping-Hua Hu  1 , Jian-Hong Tu  2 , Ni-Si Yu  3
Affiliations
Comparative Study

Luminal B breast cancer: patterns of recurrence and clinical outcome

Zhi-Hua Li et al. Oncotarget. .

Abstract

In recent years, most studies on breast cancer relapse and metastasis have focused on non-luminal breast cancers (including the basal-like and HER-2 subtypes) because of their poor prognosis. However, the luminal B subtype is more common, but this type has not been investigated as thoroughly. In the current study, we collected data on 258 patients with luminal-B breast cancer patients with recurrence and metastasis served as the observation group, and 189 patients with non-luminal breast cancer during the same period served as the control group. This study aimed to investigate the pattern of recurrence and clinical outcome after follow-up treatment for luminal B breast cancer. We found a higher proportion of local recurrence and single bone metastasis in patients with luminal B breast cancer than in patients in the non-luminal groups. The risk of recurrence and metastasis in patients with luminal B breast cancer during a 2- to 5-year period and after 5 years was still present, but the risk in patients with non-luminal breast cancers had obviously decreased during the same period. Patients with luminal B breast cancer with recurrence or/and metastasis had a better prognosis after reasonable treatment. The recurrence patterns and clinical outcomes of patients with luminal B breast cancer according to HER2 status were also different, to some degree. These results are of potential clinical relevance especially for the monitoring of clinical prognosis and targeted therapy intervention for luminal B breast cancer.

Keywords: breast cancer; luminal B subtype; prognosis; recurrence pattern.

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Conflict of interest statement

CONFLICTS OF INTERESTS

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1. Comparison of BCFI between luminal B and non-luminal breast cancer patients, HER2+ luminal B subgroup and HER2− luminal B subgroup
Figure 2
Figure 2. Comparison of PFS between luminal B and non-luminal breast cancer patients
Figure 3
Figure 3. Comparison of MSR between luminal B and non-luminal breast cancer patients with recurrence and metastasis
Figure 4
Figure 4. Comparison of PFS between HER2+ and HER2− luminal B breast cancer patients with distant metastasis
Figure 5
Figure 5. Comparison of MSR between HER2+ and HER2− luminal B breast cancer patients with recurrence and metastasis
See this image and copyright information in PMC

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Supplementary concepts